She was found guilty of three counts of wire fraud and one count of conspiracy to commit wire fraud on Jan. 3, 2022. If we did too much, we wouldnt be invited back to invest.. In short, the world once again needs many more people like Elizabeth Holmes, not fewer. Twenty pages later we read about how employees Aaron Moore and Mike Brauerly took a Theranos analyzer into San Francisco (that they did calls at least somewhat into question the authors regular assertion that Theranos brought new meaning to secretive) only to try it on contacts from the start-up community. There are also rumors that her booming deep voice is faked on purpose to garner more respect from her peers(10). Holmes was destined for an incredible future which started with her first company Theranos in 2004. . The pharmaceutical companies were going to use Theranoss blood-testing system to monitor patients response to new drugs. (5) New Book Documents the Rise and Fall of Silicon Valley Wunderkind Elizabeth Holmes | CBC Radio.CBCnews, CBC/Radio Canada, 15 June 2018, www.cbc.ca/radio/asithappens/as-it-happens-monday-full-episode-1.4671937/new-book-documents-the-rise-and-fall-of-silicon-valley-wunderkind-elizabeth-holmes-1.4671941, (6) Paradis, Norman A. Ad Choices, $100M Theranos investor did little vetting for fear of upsetting Elizabeth Holmes, Elizabeth Holmes personally approved investor presentations, court hears. Indeed, seemingly lost in all this is that after financing had dried up amid a surge of bad publicity, hedge fund Fortress made a $100 million loan to Theranos that was collateralized by Theranoss patent portfolio. As evidenced by the valuation placed on the patents, arguably Holmess biggest offense was that she wasearlyto an idea that will eventually bear fruit. Cases and Tools in Biotechnology Management Copyright by Trent Tucker. Both the trial and a 2018 agreement that Theranos entered into with the Securities and Exchange Commission (SEC), to settle earlier fraud charges, suggest investors failed to do the kind of due diligence that would be expected of them in equity deals of Theranos' scale. It was like a switch had been flipped. offers FT membership to read for free. Theranos Inc.s Partners in Blood. The Wall Street Journal. Charlotte Hu contributed to an earlier version of this post. New directors might join the board to reflect the growing roster of investors, she told him. Mosley had joined Theranos eight months earlier, in March 2006. Federal prosecutors allege Holmes and co-conspirator Ramesh "Sunny" Balwani swindled hundreds of millions of dollars from investors while knowingly misleading doctors and patients with claims of revolutionary blood-testing technology. Another problem with the amount of blood drawn itself was the composition of the blood taken from a finger prick would not have a common concentration like what would be found if taken from a vein. Mosley had joined Theranos eight months earlier, in March 2006. Although investors took a risk by not doing the level of due diligence expected of business deals of the scale Theranos represented, the absence of a CFO to help enforce financial, operational and compliance discipline played a role as well, according to a commentary by purchasing platform company Teampay. There were many problems with the management of Theranos which started out at the beginning. This technology would be able to analyze over 100 tests all within minutes at a local Walmart or Walgreens(2). The founder and chief executive of Theranos is preparing to stand trial for fraud and conspiracy to commit wire fraud, and her defense will present Holmes as the victim of Theranos's. A third of the way through Carreyrou introduces Holmess brother, Christian. She was sentenced to more than 11 years in prison and is due to surrender. Because he did, Carreyrou seemingly searched for and reported what some would deem red flags that revealed themselves on the way to 2015. Sponsor the work of leading economists and academics as they advance the study of the economic principles that underwrite human prosperity and progress via AIER.org. 46. An investor who was introduced to Theranos by former Secretary of State, Henry Kissinger, testified in Elizabeth Holmes' criminal trial. Still, Holmes worked hard throughout high school and college, she learned Mandarin in high school and worked at a graduate level lab in her first year at Stanford. 2022 J&W Associates | Sitemap (XML) | Site By Blue Dreamer. The chairman of her board was Donald L. Lucas, the venture capitalist who had groomed billionaire software entrepreneur Larry Ellison and helped him take Oracle Corporation public in the mid-1980s. After that, one senses that some of Holmess biggest critics have never run a start-up, let alone a business. There werent many three-year-old startups that could say they were worth that much. Billed as an unputdownable account of Secrets and Lies in a Silicon Valley Startup,Bad Bloodmostly amounted to a string of less-than-shocking anecdotes about life in a pressure-filled start-up. Compare Standard and Premium Digital here. Zenify Your Presentation She leveled a cold stare at her chief financial officer. With such an amazing company and reputation it dazzled many investors that were lining up to be to give Holmes money. Even though everything on the outside looked amazing for Theranos, on the inside there was a lot of trouble and ineptitude within the organization. At first, Shaunak professed not to know anything. cookies Kemp had spent thirty years at IBM. Investors put capital to work in Silicon Valley with full knowledge that just about every investment goes belly up. Harrods chief shrugs off recession fears because rich get richer, FCA regulator blamed for Arms decision to shun London listing, Argentina diary: Come armed with $100 bills, There are no domestic equity investors: why companies are fleeing Londons stock market, Clutching Warrens letter, Im still positive on stocks, The Murdaugh trial: a southern gothic tale that gripped the nation, Humanity is sleepwalking into a neurotech disaster, Who to fire? Crucial is that these people are very necessary. She liked to use the term extra-ordinary, with extra written in italics and a hyphen for emphasis, to describe the Theranos mission in her emails to staff. Theranos was a former American health technology company founded in 2003 by Elizabeth Holmes. That the technology didnt always work means itsometimes did, plus per Pixar founder Ed Catmull, all of our movies suck at first. Perhaps more notable about Pixar is that it didnt produce its first feature-length film until twenty years after the company opened its doors. When prospective investors came by, he took them to see Shaunak Roy, Theranoss cofounder. Mosley joined Theranos in part because of the high caliber of its executives, many of them technology veterans who had been involved in some of Silicon Valleys biggest success stories, according to the book, "Bad Blood: Secrets and Lies in a Silicon Valley Startup.". Considering the Walgreens clinics in Phoenix that featured Theranos technology, Carreyrou himself reports visiting one only to ask Why no finger stick? as a phlebotomist wrapped a tourniquet around his arm. SAN JOSE, CALIF. -- A former estate attorney told jurors in Elizabeth Holmes' criminal trial that he invested $6 million in Theranos after being introduced to Holmes by ex-Secretary of State Henry Kissinger. This article was initially published in May 2018 and has been updated. Sorry, but entrepreneurs are different from you and me. Learn more about how Pressbooks supports open publishing practices. Elizabeths expression suddenly changed, Carreyrou said in the book. Mosley's testimony continues on Wednesday. It wasnt just the board and the executive team that had sold Mosley on Theranos, though. He brought up what Shaunak had told him about the investor demos. By 2005 Balwani and Holmes were living together and by 2009 Balwani joined Theranos as the chief operating officer. Source: Business Insider, Business Insider, Foto: Tim Draper defends Theranos on CNBC in 2018.sourceCNBC, Foto: sourceJammy Photography / Shutterstock, Foto: Protein analysis tubes are seen in a lab at the Institute of Cancer Research in Sutton, Britain.sourceReuters, Foto: Footage of Sunny Balwani presenting.source"60 Minutes", Foto: A pharmacist stands in the background as a sign rests on a counter at a Walgreens pharmacy store in Austin, TX, U.S., March 26, 2018sourceReuters/Mohammad Khursheed, Foto: Theranos founder Elizabeth HolmessourceCourtesy HBO, Foto: sourceUS Air Force/Staff Sgt. Its quite simply not news that Thernanos technology was buggy. Thankfully they are. Quoting Thiel again, humans are distinguished from other species by our ability to work miracles. She was also convicted on one charge of conspiracy to commit wire fraud against investors. ET, Presented by studioID and Dun and Bradstreet, Nikola fined $125M for founder's exaggerations, Musk tweets violated SEC rules, WSJ reports, CEO, CFO of electric truck maker Lordstown resign; misleading demand alleged, CFOs step up as companies look for strategic guidance, CFOs struggle to move past transactional responsibilities, Economists push back estimated recession date: NABE, CFO best practices: Biggest lessons for 2023, Digital transformation in todays finance landscape, How CFOs are using sustainability goals to drive investments, Are US Interest Rates Going Up? Softbank is the largest tech investorin the world, with a war chest of more than $100 billion in two capital funds. One of those executives was Henry Mosley, Theranoss chief financial officer. They were concerned about the false results that would be given to the oncology patients in this trial and wanted to cancel the plan. Word of the demos success made its way upstairs to the second floor, where senior executives offices were located. Pond Technologies Inc. - Target Markets, 34. (9) Carreyrou, John. Indeed, in his excellent biography of Orville and Wilbur Wright, titledThe Wright Brothers, David McCullough wrote of how the would-be conquerors of the air and their strange or childish flying machines served as a continuous source of popular comic relief to the wise. Time is plainly of the essence, while money is generally always a worry. These were hardly widows and orphans. Some readers will read these passages as sinister, but they might read them differently if aware that Knight routinely talked of my kingdom for liquidity. While most readers became familiar with KnightafterNike was established as a global brand, and with Holmes in the same way, its not unreasonable to suggest that Holmess memory of East Palo Alto, of the aforementioned roofing contractor across the street from Theranoss initial headquarters, of arriving to work with glass shards in her hair after a bullet plainly meant for someone else crashed her own cars window, informed her desire to avoid bad publicity. TAXA Biotechnologies Inc.: A Genetic Engineering Start-up, 20. CNMN Collection That Theranos allegedly didnt always check with authorities ahead of testing isnt a surprise, nor does it besmirch the company as the author seemingly presumes. Based on the few interactions Mosley had had with him, it was clear Robertson thought the world of Elizabeth. The response to them from this reader was mostlyso what? Get this delivered to your inbox, and more info about our products and services. I think you should leave right now.. Premium access for businesses and educational institutions. Over its roughly 15 years, the company attracted almost $1.5 billion in capital, much of it from some of the most experienced investors in Silicon Valley, including a $100 million credit line in 2017 from Softbank-funded Fortress Investment Group, which took a 4% equity stake. Theranoss crimes were discovered by Wall Street Journal writer John Carreyou who was able to expose Holmes fraud(12). Simply log into Settings & Account and select "Cancel" on the right-hand side. Weve been fooling investors. Keep up with the story. So theyd recorded a result from one of the times it worked. university The value finance leaders bring to operations is varied but they share a forward-looking vision. This occurred when a major drug company made a deal with Theranos in 2008 to test its technology for a study on stage 3 and 4 cancer patients(7). I could not be more impressed with what you have accomplished and what lies ahead for Theranos, he said. Investors poured some $1.5B into Elizabeth Holmes' blood-testing startup despite the absence of a finance chief. A Case on AncestryDNA, 27. Mosley didnt really grasp the physics or chemistries at play. Using Statistics Canada and Interpreting Data to Generating Graphs, 17. Holmes was able to attract the best and brightest to her employ and to her board precisely because she wasnt lacking in confidence about what could be achieved. The following is excerpted from the recently-published BAD BLOOD: Secrets and Lies in a Silicon Valley Startup 2018 by John Carreyrou. Published by at June 13, 2022. Turing Pharmaceuticals: a glimpse into controversial drug pricing. All Holmes said to them was to follow suit with the company or resign, they both resigned in 2008. journalists in 50+ countries covering politics, business, innovation, trends and more. Epidermolysis bullosa Rare Disease and big Business, 42. Looked at through the lens of Theranos, Holmes never hid from her desire to revolutionize how blood is drawn, the amount of blood drawn in order to access all manner of information about an individuals health, and as a consequence, Holmes and Theranos aimed to once again save lives by detecting health problems early all the while using information gleaned from the pin prick to enable more bespoke drug regimens. In 2014, Henry Mosley, a lawyer and power broker from wealthy families, requested audited financial statements from Theranos, but she failed to provide any of his investments. Henry, youre not a team player, she said in an icy tone. The way she trained her big blue eyes on you without blinking made you feel like the center of the world. Tim De Chant Looked at another way, a lack of disdain for Holmess vision would have been a likely sign that Holmes was in possession of a fairly pedestrian idea. Did they really think Theranos would have gotten as far as it did had Holmes been mostly nonchalant about her vision? A start-up that attains backing is almost by definition one with designs on rewriting how things are done in a way that totally rejects how things are presently done (thus setting oneself up for all manner of criticism on the way up), expertly filling needs previously unmet, on the way to the capture of outsize profits. This week, Elizabeth Holmes, the founder of Theranos was found guilty of 4 counts of fraud in a US court. The former IBM executive was in charge of bioinformatics at Theranos, a startup with a cutting-edge blood-testing system. Not so fast. Robert Freedman When have different thinkers ever gotten it right the first time? Terms & Conditions! It included the promises Theranos made to investors. One of those executives was Henry Mosley, Theranos's chief financial officer. TreasurySpring and ICD partner to add Fixed-Term Funds to the ICD platform, Examining The Treasury Recruitment Companys Global Treasury Salary Survey Webinar, 10 Best Practices for a Successful Client Conversion Experience, Navigating financial instability during the COVID-19 pandemic, 3 more rate hikes are coming, according to Goldman Sachs - TREASURY NEWS - OpenTreasury Podcast #77. In November 2006, Henry Mosley was fired from the position of chief financial officer at Theranos after questioning the reliability of its technology and the honesty of the company. One of the major problems with this was that Balwani did not have any training in medical or biological science. Then there was the Pfizer report. For a full comparison of Standard and Premium Digital, click here. Wade pressed Mosley further on his vetting process, showing him various webpages from Walgreens and Theranos that contained footnotes disclaiming that venous draws may be used instead of finger pricks. "I thought the company had enormous potential for good in the world, for being able to do this sort of testing as described," Mosley said. The high-profile fraud trial of Theranos startup founder Elizabeth Holmes exposes a shadow side of leadership that undermines healthy workplace culture, according to Linda Neider, chair of the Miami Herbert Business School's Management Department. After growing up in the Washington, D.C., area and getting his. (4) The Nobel Prize in Chemistry 1980.NobelPrize.org, www.nobelprize.org/prizes/chemistry/1980/gilbert/biographical/. About the analysis that youre about to read, its mine and mine alone. Carreyrou tracks the incredible rise of Holmes, from 19-year-old college drop-out with little or no medical experience, to CEO of an innovative healthcare startup that was set to revolutionise diagnostic blood testing and was valued at more than $11 billion by the time Holmes was 29. The story culminates in a series of investigative reports by journalist John Carreyrou, with the input from the whistleblowers, such as Erika Cheung, Henry Mosley, and Tyler Shultz, etc, which expose the truth about Theranos and lead to the downfall of the company. This fiction culminated in 2014 when Theranos issued a projection claiming $1 billion in revenue in 2015, a number that was absurdly unreasonable given that its revenue in 2014 was around $100,000 and its contracts were shrinking rather than growing.. John Howard, the senior vice president for products, had overseen Panasonics chip-making subsidiary. He realised he had seen no proof such as pharmaceutical contracts that Theranos's system was reliable and what's more, he had slightly inflated revenue forecasts, at Holmes's request, because he had believed that the reliability of the Theranos system would make these higher forecasts possible. Lets never forget that any truly entrepreneurial venture is going to leave behind countless skeptics along the way, and for obvious reasons. The gap between appearance and reality, which Mosley tried to close before he was fired, is ultimately what brought down the fast-growing company. Ku was bothered that Theranos technology was being used in experimental fashion, but its a speculation that most wouldnt be. |. K&N's: A Vertically Integrated Business Approach, 39. But Carreyrou's book also highlights the role of Henry Mosley, the chief financial officer at Theranos who was fired by Holmes in November 2006 for questioning the reliability and integrity of the company's lab-testing systems and equipment. It seems Carreyrou and his many devoted readers rushed to the story of Theranos without considering how different its evolution might have been had its ascent been quieter, slower, surely more fraught from a financial standpoint, but for being fraught it not attracting so early the attention of politicians, eminences, reporters, etc. My understanding is, the blood would be tested on the Edison device, he said, according to the Washington Post. That report, despite sporting the companys logos, had in fact been prepared by Theranos and included claims that werent supported by Pfizers scientists. In the absence of that due diligence, he indicated during the trial, he was surprised to learn the company was using outside technology to do much of its testing. All Rights Reserved. Big Pharma and Biotech: A match made in heaven? See the complete profile on LinkedIn and discover Henry's . Or the second, third, orthousandthtime? Lots of luck finding backing. This matters a great deal. I am not discouraged, because every wrong attempt discarded is just one more step forward. Carreyrou notes that Holmess had a Michael Jordan quote up on the walls of Theranoss headquarters which said Ive failed over and over again in my life. Early employee Shaunak Roy indicated to Carreyrou that Holmess vision bordered on science fiction, biochemist and chief scientist Ian Gibbons told his wife Rochelle that nothing at Theranos was working, while lab director Alan Beam similarly told the author Theranos devices didnt work.. Holmes told her employees that the results wouldnt impact the patients but there a few who knew that it was a lie. 2021 American Institute for Economic ResearchPrivacy Policy, AIER is a 501(c)(3) Nonprofit registered in the US under EIN: 04-2121305. Former Theranos CEO Elizabeth Holmes leaves a federal court after a status hearing on July 17, 2019 in San Jose, California. If the results indicated a bad reaction to the drug, the drugs maker would be able to lower the dosage immediately rather than wait until the end of the trial. This was a pivotal moment for Theranos. "I told the individuals I introduced that Elizabeth is somebody I had come across, I was impressed with her idea and technology and this is somebody I thought they would enjoy meeting," Mosley said. In addition, Alice Walton, the world's richest woman, who owns 70% of Walmart, as a member of the founding family invested in the company. Prosecutors showed a binder that was given to Mosley. Mosley testified that Holmes was looking for "high-quality families" to invest. How the biggest companies plan mass lay-offs, The benefits of revealing neurodiversity in the workplace, Tim Peake: I do not see us having a problem getting to Mars, Our ski trip made me question my life choices, Michelle Yeoh: Finally we are being seen, Apocalypse then: lessons from history in tackling climate shocks, How Glasgows tiny, muckraking crime mag stays afloat. Elizabeth was often upbeat. Its former CEO and founder Elizabeth Holmes faces criminal charges stemming from allegations that she and. Holmes defense attorney Lance Wade asked Mosley whether he confirmed the report with Pfizer itself, and Mosley admitted that he had not. All Rights Reserved. The most extensive evidence supplied regarding the reliability of the Theranos technology and its application is a Study Report prepared by Pfizer based on a clinical cancer treatment trial, Mosley wrote to Kissinger. (1) ABC News, ABC News Network, abcnews.go.com/Business/theranos-employees-describe-culture-secrecy-elizabeth-holmes-startup/story?id=60544673, (2) Paradis, Norman A. henry mosley theranos. Considering what some would describe as Theranoss collapse, its worth remembering (though its not emphasized inBad Blood) that just about every Silicon Valley start-up fails. Got a confidential news tip? Hot Startup Theranos Has Struggled With Its Blood-Test Technology.The Wall Street Journal, Dow Jones & Company, 16 Oct. 2015, www.wsj.com/articles/theranos-has-struggled-with-blood-tests-1444881901. Its all a reminder that while Holmess was plainly and understandably not eager to shout the initial shortcomings of Theranos technology to all who would listen, its not as though she was going out of her way to bury mistakes without addressing them. This was news to Mosley. Mosley was fired for doing his job. Issues with management style are the norm within all companies, and dont in isolation mean much. How Important is Privacy? His inexperience in biological science showed itself to the top researchers at the company as he was seen to be clueless in meetings especially as a top executive (10). Mosley was distraught as he also realized he had never seen any evidence of their technology working and that he had inflated future revenues due to his confidence in Holmess idea(5). he said to jurors. If the answer is that Holmes ran off the skeptics as the author seems to allude, even thats a reach as an indicator of something bigger. Dont you get it? Centocor: Commercializing Monoclonal Antibodies, 38. It showed revenue stagnating for a few years and then magically shooting up in a straight line. Diane Parks, Theranoss chief commercial officer, had twenty five years of experience at pharmaceutical and biotechnology companies. In a New York Times report, even sophisticated funds putting in tens of millions of dollars did so on faith, in part because of investment agreements giving Holmes the right to decide who would be in, and who would be out, the next time the company raised capital. Assuming once again a different ending for Theranos, how would Carreyrou the skeptic write Beam, Gibbons, Ku and Shultz? When Mosley questioned his staff, he found out that they were unhappy because they had to pre-record the demonstration and lie to Novartis because Theranoss technology was often faulty and wouldnt work. By any measure, it was a resounding success: the company had raised another $32 million from investors, on top of the $15 million raised in its first two funding rounds. "And I obviously had clients who would have a similar view as mine.". That was certainly what the investors he brought by were led to believe. And its arguable that they should view the heights reached by Theranos at one time as a very positive outlier precisely because, as Carreyrou somewhat self-righteously contends throughoutBad Blood, lives are at stake when it comes to healthcare. Mosley saw an opening to broach the trip to Switzerland and the office rumors that something had gone wrong. What Shaunak had just described sounded like a sham. No chance. Steve Ballmer, CEO Microsoft, 2007) ahead of launch. Mosleys unease with all these claims had grown since that mornings discovery. Join the Ars Orbital Transmission mailing list to get weekly updates delivered to your inbox. organisation We cant keep doing that, he told her, according to Carreyrou. 5. The first set of numbers hed come up with hadnt been to her liking, so hed revised them upward. "No.". Did someones puppy get run over? And while the story of Ian Gibbons is very tragic, its presumably a consequence of much more than his employment at Theranos that didnt end well. Jobs also had Steve Wozniak who was a gifted computer engineer that Jobs had highly respected, Holmes did not have anyone with such expertise that she trusted at Theranos(11). Subscribe today. For cost savings, you can change your plan at any time online in the Settings & Account section. Once the poster child for Silicon Valley entrepreneurship, Elizabeth Holmes appeared . He was a little uncomfortable with the revised numbers, but he figured they were in the realm of the plausible if the company executed perfectly. However, it was more likely to ensure that other employees dont piece together the failure of their technology. Besides, the venture capitalists startups courted for funding knew that startup founders overstated these forecasts. To learn more about how we use your information, please read our privacy policy. There was no mistaking what had just happened. One of her original investors, venture capitalist Tim Draper, has made plain that he would back her again. Business The Story A needle, a tiny prick, and real-time bloodwork analysis. Through the years Theranos would slowly progress into a billion-dollar company and make Holmes a hero in the medical community and celebrity everywhere else. Its also a near certainty that theres no Alan Beam, Ian Gibbons, and Edmond Ku accepting the Theranos recruiting pitch, and theres no Tyler Shultz simply because theres no George Shultz. Standard Digital includes access to a wealth of global news, analysis and expert opinion. And in today's Finshots, we explain how a Silicon Valley-based startup that promised to revolutionise blood testing crashed and burned. To miniaturize the iPod Jobs had a supplier and manufactures at hand. They invested with eyes wide open. If Theranos could make itself indispensable to them and capture a fraction of that spending, it could make a killing. Mosley testified on Tuesday that he hadnt pushed his clients to invest, but he was clearly smitten with the company and its founder, according to emails shown to the court. By 2014 Theranos would be evaluated at $9 billion dollars and have an all-star cast of a board of directors containing 2 former secretary of states and 2 united states senators which gave Theranos even more fame and credibility(1). Source: Business Insider, Business Insider. Few will admit it, but degrees are credentials that confirm someone learned yesterdays news very well, or passably well in many instances. One slide said, "Theranos has been comprehensively validated over the course of the last seven years by 10 of the 15 largest pharmaceutical companies, with hundreds of thousands of assays processed. or Queensland University of Technology: Funding a Golden Opportunity, 28. Didnt it always seem to work when investors came to view it? In 2004 a second-year Chemical Engineering student at Stanford University decided that continuing her education would no longer be useful for her. 09-15-2021. Both have pleaded not guilty. Ive also briefly spoken with Elizabeth Holmes a few times over the years, but other than words of encouragement have never discussed Theranos with her in any substantive way. This along with Sunny Belwani also berating the employees when he himself had very little knowledge of anything Theranos was doing led to a toxic work environment. The trial was briefly interrupted by a man who took a photograph inside the federal courtroom in San Jose, California. (12) Carreyrou, John. When he confronted Holmes about the problem, she fired him for not being a team player. The big problem with this was that the technology would never work as it was nearly impossible. Aleafia Health Inc.: A Novel Approach in Medical Cannabis, 47. Ti thng 7/2007, Theranos cho bit s kin . No doubt this makes for a page turner in the eyes of some, but it doesnt explain much beyond that other than Carreyrou needed a story to connect to an end result. What about Theranoss other blue chip investors? The vast majority of that money was invested after Holmes fired the companys one and only CFO., Get the free daily newsletter read by industry experts. His first job was at chipmaker Intel, one of the Valleys pioneers. A look at mergers and acquisitions as strategies for sustainable growth in the pharma industry.

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henry mosley theranos